How to Increase Klotho Protein Levels in the Body

Klotho protein is a naturally occurring substance in the body that has been described as an “anti-aging protein” by scientists. Due to its effects on age-related health, researchers are investigating the role of klotho protein in various biological systems for its role in:

• Anti-aging
• Longevity
• Brain function

Animal studies have shown clear differences between mice with lower levels of klotho protein and mice with higher levels of klotho protein. Mice that have been bred to produce higher levels of klotho protein have been observed to have:

• Longer lifespan
• Increased cognitive function, including learning and memory
• Increased resistance to oxidative stress, a risk factor for cancer
• Mice that have been bred to produce lower levels of klotho protein were noted as experiencing:
• Early death
• Impaired cognitive abilities
• Osteoporosis
• Infertility
• Quicker aging

Knowing what we know about klotho protein, this might make you wonder: How can you increase your klotho protein levels? Below are some guidelines on how you may be able to do this:

1. Exercise

Scientists have found that regularly participating in aerobic exercises, such as walking, running, and cycling, increases the level of klotho protein that circulates throughout the bloodstream. Increased levels of klotho protein are linked to a reduced risk of cardiovascular disease, the number one cause of death in the US.1 It has long been known that consistent, aerobic exercise helps reduce the risk of cardiovascular disease for various reasons, such as weight management and reducing blood pressure. However, this research reveals a previously unknown benefit to exercise.

2. Take Probiotics

Probiotics are live bacteria that help promote healthy digestion throughout the gastrointestinal tract. The correct balance of helpful bacteria help strengthen the immune system and can even help prevent some illnesses, such as the cold or flu. Certain probiotics, like lactobacillus acidophilus and bifidobacterium bifidum, have been proven to activate expression of the klotho gene, which produces klotho protein. Probiotics naturally occur in foods like yogurt and sauerkraut or can be purchased as supplements.

4. Klotho Therapy

A new therapy may have the ability to increase the amount of klotho protein in the body. Klotho therapy is currently under development by laboratories like Klotho Therapeutics in order to potentially prevent age-related diseases, like cardiovascular disease, kidney disease, and dementia. Klotho therapy involves administering klotho protein to individuals who naturally have lower levels of klotho protein, or to individuals who may need to replace declining levels of klotho protein, in order to prevent the onset of age-related disease.

The Future of Klotho Therapy

Although various studies have shown the ability of klotho protein to delay the development of age-related complications, currently, there is no klotho therapy available to the public. This therapy is still in the research phase, and scientists are hopeful that they can make a treatment available to humans in the near future.